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c/semaglutide·posted 1 year ago by u/rasmus_kimani

food noise: what the trials say vs what this community says

Discussion Long Haul ×1 Well Actually ×2 Cold Box ×2

Been lurking in c/dosinglogs for about 15 months and finally have something worth posting.

Short version: week 11, 0.5mg, and titration is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 33 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 5.

3,462 up / 844 down80% upvoted28 commentsid 1afawk19 Dec 2024

28 comments

12 in this archive, depth 3

best — the order this archive was captured in

u/rohan_steiner274 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/rasmus_kimaniOP202 points·1 year ago

okay but what dose of sema are you on

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u/rasmus_kimaniOP-1 point·1 year ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/marit_coelho179 points·1 year ago

week 67 and i am still not at maintenance, do not rush the ladder

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u/iman_castellanos146 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/katrin_diallo114 points·1 year ago

week 86 and i am still not at maintenance, do not rush the ladder

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u/throwaway_titration109 points·1 year ago

okay but what dose of sema are you on

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u/rasmus_kimaniOP94 points·1 year ago

Tried the split-dose thing for 20 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

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u/rasmus_kimani124 points·1 year ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/bilal_osei0 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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u/lane_map_larrylogistics124 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/nikhil_teixeira31 points·1 year ago

week 93 and i am still not at maintenance, do not rush the ladder

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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