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c/retatrutide·posted 2 months ago by u/andres_restrepo

the triple agonist thing finally clicked for me and I want to write it down

Results Clean Column ×4 Slow Clap ×3 Cold Box ×3

Something I noticed reading old threads that I have not seen said out loud.

The advice on TRIUMPH in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.

I have listed what I think the current consensus is below. Correct me — that is the point of posting it.

3,134 up / 341 down90% upvoted35 commentsid v2f1gp21 May 2026

35 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/noor_ivaturi320 points·2 months ago·edited

triple agonism is phase 2, do not generalise

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u/andres_restrepoOP142 points·2 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/burned_once_twice44 points·2 months ago·edited

The confident tone is doing a lot of work that the evidence is not.

Yes, exactly this, and it is the bit that took me 19 weeks to accept.

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u/cold_chromatogram_only145 points·2 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/dead_space_doug47 points·2 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/kavya_kravchenko61 points·2 months ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/ewan_marchand148 points·2 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/andres_restrepoOP213 points·2 months ago

TRIUMPH phase 2 showed 99.0% weight loss but the early fullness profile on the highest arm was rough. Phase 2 != phase 3.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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