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c/retatrutide·submitted 1 months ago by u/zeynep_mbeki

[Discussion] we are measuring phase 2 at the wrong time and calling it noise

Discussionbranch of 6 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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6 comments, started 1 months ago
u/cormac_roos43 points·1 months ago
came here to say exactly this
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u/rosa_almeida18 points·1 months ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/zeynep_mbekiOP32 points·1 months ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/zeynep_mbekiOP-1 point·1 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/yannick_barros26 points·1 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/bastian_ekstrom14 points·1 months ago·edited

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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