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c/retatrutide·submitted 1 months ago by u/zeynep_mbeki

[Discussion] we are measuring phase 2 at the wrong time and calling it noise

Discussionbranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against eGFR for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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9 comments, started 1 months ago
u/niels_lindqvist17 points·1 months ago
this deserves more than 8 upvotes
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[removed]13 points·1 months ago

[removed by moderator]

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u/jarno_cabrera6 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/employer_carveout4 points·1 months ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/jarno_cabrera2 points·1 months ago

This is correct. Triple agonism is genuinely different.

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u/zeynep_mbekiOP2 points·1 months ago

triple agonism is glucagon, do not generalise

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u/customs_seizure_sid3 points·1 months ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/zeynep_mbeki7 points·1 months ago

the dosing is steep, the early fullness reports are real, and nobody knows the human safety yet

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u/janek_ferrari10 points·1 months ago

TRIUMPH phase 2 showed 99.0% weight loss but the constipation profile on the highest arm was rough. Phase 2 != phase 3.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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