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c/retatrutide·submitted 8 months ago by u/viktor_laurent

small win: triple agonist stopped being a problem at week 61

Discussionbranch of 9 comments

Quick one. Canada here. glucagon works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 8 weeks and cost roughly what I expected. The admin was worse than the…

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9 comments, started 8 months ago
u/jarno_cabrera1k points·8 months ago
post the spreadsheet
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u/reta_and_regretMOD549 points·8 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/viktor_laurentOP325 points·8 months ago

heart rate and dose escalation need actual measurements, not impressions

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u/nausea_notesside effects270 points·8 months ago

the 12.5mg arm is different from 5mg, results do not transfer

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u/liver_enzyme_liz217 points·8 months ago·edited

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/viktor_laurentOP589 points·8 months ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/tired_ledger_notes134 points·8 months ago

research use only, handling and analysis, not protocols

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u/viktor_laurentOP68 points·8 months ago

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/crosspost_bot_no50 points·8 months ago·edited

This is correct. Triple agonism is genuinely different.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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