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c/retatrutide·posted 1 months ago by u/nadia_trevino

what would you tell week-1 you about triple agonist

Discussion

Week 12 update. 13kg down from the start, muscle cramps basically gone since about week 52.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

0 up / 0 down43% upvoted7 commentsid todvhv23 Jun 2026

7 comments

7 in this archive, depth 5

best — the order this archive was captured in

u/renzo_yildiz4 points·1 months ago

Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.

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[removed]2 points·1 months ago

[removed by moderator]

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u/arne_amankwah6 points·1 months ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/reta_and_regret4 points·1 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/aa_analysis_andy2 points·1 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/nausea_notesside effects-37 points·1 months ago

the 1.0mg arm is different from 0.5mg, results do not transfer

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u/ewan_zielinski3 points·1 months ago·edited

the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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