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c/retatrutide·submitted 1 year ago by u/halima_mbeki

[Results] 2 weeks, 11kg, and glucagon was the hard part

Resultsbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 21 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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6 comments, started 1 year ago
u/reta_and_regret24 points·1 year ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/reflux_report19 points·1 year ago

This is correct. Triple agonism is genuinely different.

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u/honest_syringe3320 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/priya_weiss14 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/heart_rate_bump17 points·1 year ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/iman_castellanos13 points·1 year ago·edited

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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