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Single comment threadYou are looking at one branch of my A1c moved and I cannot work out whether glucagon is why — 36 comments in the full submission. View in context.
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c/retatrutide·submitted 25 days ago by u/arne_amankwah

my A1c moved and I cannot work out whether glucagon is why

Cautionbranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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6 comments, started 25 days ago
u/incretin_ivyMOD105 points·25 days ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/yannick_barros82 points·25 days ago

Not convinced. The evidence does not support that reading.

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u/janek_ferrari65 points·25 days ago

Small correction: the trial was 21 weeks, not 37. Does not change your point but people will quote it.

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u/viktor_laurent73 points·24 days ago·edited

the 1.7mg arm is different from 2.4mg, results do not transfer

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u/trialwatch_theotrial nerd19 points·24 days ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/aa_analysis_andy24 points·25 days ago

Removed a chain here.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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