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c/retatrutide·posted 16 days ago by u/naomi_erdogan

[Meta] proposal — a flair for retatrutide posts

Trial Data Receipts ×9 Slow Clap ×1

Genuinely asking, not being difficult.

Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 18 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

1,918 up / 243 down89% upvoted38 commentsid 1y71b913 Jul 2026

38 comments

17 in this archive, depth 6

best — the order this archive was captured in

u/two_mil_or_one179 points·16 days ago

What was the dosing schedule in that arm?

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u/nikhil_asante-12 points·16 days ago

This is correct. Triple agonism is genuinely different.

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u/lurker_for_years161 points·16 days ago

What was the dosing schedule in that arm?

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u/naomi_erdoganOP63 points·15 days ago

phase 2 numbers are not maintenance numbers, cite the trial

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u/lina_bruun91 points·15 days ago

triple agonism is phase 2, do not generalise

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[deleted]59 points·15 days ago

[deleted]

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u/lurker_for_years109 points·15 days ago

nobody should be giving this to anyone without extensive monitoring

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u/bastian_ekstrom65 points·15 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/marit_laurent38 points·15 days ago

triple agonism is glucagon, do not generalise

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u/honest_syringe_202522 points·15 days ago

Did you actually measure heart rate or is that a feeling?

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u/hugo_pires18 points·15 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/kofi_balogun24 points·15 days ago

nobody should be giving this to anyone without extensive monitoring

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u/two_mil_or_one37 points·15 days ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/naomi_erdoganOP14 points·15 days ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/yannick_barros12 points·15 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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