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Single comment threadYou are looking at one branch of 12 months in and triple agonist is still the thing I get wrong — 41 comments in the full submission. View in context.
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c/retatrutide·submitted 2 years ago by u/incretin_ivy

12 months in and triple agonist is still the thing I get wrong

Trial Databranch of 12 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab,…

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12 comments, started 2 years ago
u/ewan_zielinski563 points·2 years ago
this deserves more than 19 upvotes
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u/lurker_for_years341 points·2 years ago

triple agonism is phase 2, do not generalise

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u/sena_teixeira286 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/elodie_grimaldi89 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/incretin_ivyOPpharmacology36 points·2 years ago

What was the dosing schedule in that arm?

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u/lurker_for_years218 points·2 years ago

Which trial arm and what was the n?

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u/bastian_ekstrom69 points·2 years ago·edited

heart rate and dose escalation need actual measurements, not impressions

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u/incretin_ivyOPpharmacology94 points·2 years ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/two_mil_or_one131 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/liver_enzyme_liz155 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/rui_only_ro109 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/source_or_silence55 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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