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c/retatrutide·submitted 2 years ago by u/incretin_ivy

12 months in and triple agonist is still the thing I get wrong

Trial Databranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking retatrutide against triglycerides for 9 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab,…

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9 comments, started 2 years ago
u/incretin_ivyMOD1.7k points·2 years ago

Retitled to remove editorialising. Put the evidence in the body.

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u/bastian_ekstrom379 points·2 years ago

Retitled to remove editorialising.

Adding to this: TRIUMPH is doing more work than the comment implies.

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u/rosa_almeida254 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/employer_carveout-10 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/kavya_kravchenko112 points·2 years ago

Not to be pedantic but dose escalation and phase 2 are being used interchangeably and they are not interchangeable in real life.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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