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c/retatrutide·posted 2 years ago by u/renzo_yildiz

[Discussion] dose escalation is doing more work than we give it credit for

Discussion Long Haul ×8 Cold Box ×3 Slow Clap ×1

Posting this because I searched for it and got nothing useful.

Setup: 0.25mg, week 96, injection-site soreness present but not ruining anything. I changed exactly one variable — TRIUMPH — and tracked it for 24 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

6,736 up / 546 down93% upvoted29 commentsid 1ahtny5 Dec 2023

29 comments

10 in this archive, depth 3

best — the order this archive was captured in

u/nabila_bakken1.1k points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/liver_enzyme_liz386 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

Yes, exactly this, and it is the bit that took me 37 weeks to accept.

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u/discount_math_dm135 points·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/incretin_ivyMOD918 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/sena_teixeira557 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/arne_amankwah274 points·2 years ago

This is correct. Triple agonism is genuinely different.

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[deleted]237 points·2 years ago

[deleted]

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u/halima_mbeki213 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/injection_site_iris75 points·2 years ago

the weight curves are unusually steep, which makes predicting individual response harder

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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