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c/reconstitution·posted 1 year ago by u/tomas_kimani

reconstitution vs mg/mL — genuinely asking which matters more

PSA Well Actually ×1 Sourced ×3 Clean Column ×2

I have had 16 orders now and I keep a table, so here is the honest summary rather than a vibe.

Material has been consistent. Communication has not. Shipping has varied by about 40 days on nominally the same lane, which matters more in summer than in February.

The independent number came back 98.4% against a claimed 97.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.

Batch number is in the comments. Ask if you want the method.

4,605 up / 951 down83% upvoted42 commentsid l59c0u18 Aug 2024

42 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/honest_syringe_20250 points·1 year ago

show your working or it is unhelpful

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u/katrin_marchetti1 point·1 year ago

Respectfully this is a sample of one presented as a finding.

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u/rosa_mensah1 point·1 year ago

Small correction: the trial was 5 weeks, not 5. Does not change your point but people will quote it.

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u/saskia_rahimi395 points·1 year ago·edited

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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[removed]151 points·1 year ago

[removed by moderator]

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u/zaid_balogun124 points·1 year ago

show your working or it is unhelpful

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u/quarter_dose_queenlow and slow205 points·1 year ago

dead space is real and the syringe matters

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u/arne_restrepo110 points·1 year ago

Spent 2 weeks confused about concentration math until someone showed me the table. 20mg, 2mL, concentration is 20/2.

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u/georgi_adebayo45 points·1 year ago

Are you using a u-100 or u-40 syringe? That changes everything.

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u/andres_sorensen45 points·1 year ago

stopper coring on the 10th draw because you keep using the same entry point. rotate.

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u/rasmus_mensah28 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/runa_grimaldi10 points·1 year ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/andres_sorensen77 points·1 year ago

Reconstituted at 2mL when I meant 21mL. Caught it because the units looked wrong. Write the concentration.

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u/tomas_kimaniOP42 points·1 year ago

Yeah, showing the arithmetic is the fastest way for someone to spot the error.

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u/swirl_dont_shakeMOD59 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/priya_weiss33 points·1 year ago

Removed a chain here.

Yes, exactly this, and it is the bit that took me 74 weeks to accept.

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u/karl_fischer_kev11 points·1 year ago

more water means more units for the same dose, which means finer resolution

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u/bac_water_banditreconstitution48 points·1 year ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/emil_zamora17 points·1 year ago·edited

30mg vial, 2mL water, concentration is 30/2 — write it on the vial afterwards

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u/batch_number_bertievetting57 points·1 year ago

Two vials, two different concentrations, forgot which was which, almost made a 21 times error. Now I label everything.

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u/sofia_danquah28 points·1 year ago

bacteriostatic and sterile water are not interchangeable, do not use them that way

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u/cesar_ivaturi27 points·1 year ago

more water means more units for the same dose, which means finer resolution

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u/ismael_nwosu23 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/freya_onwuka27 points·1 year ago

i am begging people to write down the concentration

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u/lyophile_lou27 points·1 year ago·edited

more water means more units for the same dose, which means finer resolution

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About c/reconstitution

The arithmetic and the technique. Bacteriostatic versus sterile water, reconstitution volume as a concentration choice, converting mg/mL into insulin-syringe units, dead space, swirl-not-shake, stopper coring, and how long a reconstituted vial is actually good for. Math errors get corrected fast and politely.

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