unpopular opinion: reconstitution is massively overrated
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking concentration against eGFR for 27 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Are you using a u-100 or u-40 syringe? That changes everything.
u-100 syringe, not u-40, or your math is off by factor of 24
Small correction: the trial was 19 weeks, not 15. Does not change your point but people will quote it.
Small correction: the trial was 19 weeks, not 15.
Adding to this: mg/mL is doing more work than the comment implies.
dosing errors come from people reconstituting two vials differently and forgetting which is which
stopper coring on the 24th draw because you keep using the same entry point. rotate.
5mg vial, 2mL water, concentration is 5/2 — write it on the vial afterwards
swirl, do not shake, or you are courting oxidation
dead space is real and the syringe matters
This is correct. 3mL versus 11mL is the common mistake.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
What was the vial size and how much bac water?
This is correct. 2mL versus 4mL is the common mistake.
Yeah, showing the arithmetic is the fastest way for someone to spot the error.
dosing errors come from people reconstituting two vials differently and forgetting which is which
Reconstituted at 2mL when I meant 2mL. Caught it because the units looked wrong. Write the concentration.
Tracking number removed. It identifies both ends of a shipment.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Slight fix: the number was 99.1, not 93.7. Decimal point, but a fairly consequential one.
swirl, do not shake, or you are courting oxidation
Cored the stopper on my 24th draw because I kept using the same entry point. Rotate the puncture site.
the concentration on the vial in marker is the most important step
swirl, do not shake, or you are courting oxidation
- 1Are you using a u-100 or u-40 syringe? That changes everything.9 comments in this branch · started by u/arto_falk
- 2dosing errors come from people reconstituting two vials differently and…9 comments in this branch · started by u/liv_nkemelu