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c/orforglipron·posted 6 months ago by u/aksel_kjaer

the small molecule question that gets asked weekly, answered properly

Paper Receipts ×1 Slow Clap ×2

Trying to settle this properly because the thread from last year went in circles.

The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 20 months without either producing anything.

What would actually settle it is 15 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

2,386 up / 864 down73% upvoted40 commentsid zbxi447 Jan 2026

40 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/trialwatch_theotrial nerd322 points·6 months ago

Strongly agree. The supply impact would be huge.

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u/aksel_kjaerOP212 points·6 months ago

Came off after 18 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/ravi_sandvik69 points·6 months ago

Respectfully this is a sample of one presented as a finding.

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u/erez_yilmaz169 points·6 months ago

Which country? Half the answers in this thread only apply in Denmark.

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u/scam_taxonomyc/scamalerts41 points·6 months ago·edited

Yeah, small molecule changes the whole game.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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