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c/orforglipron·submitted 5 days ago by u/chidi_yilmaz

[Trial Data] ATTAIN-1 numbers, and why the % is not the headline

Trial Databranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking orforglipron against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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9 comments, started 3 days ago
u/nils_ferreira24 points·3 days ago

Genuine question — what concentration were you at?

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u/hana_lehtinen15 points·3 days ago

phase 12 data is interesting, phase 26 will tell the real story

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u/neha_mwangi5 points·3 days ago

Strongly agree. The supply impact would be huge.

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u/freya_marchand-15 points·3 days ago

no cold chain means ATTAIN, if approved

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u/salma_almeida0 points·3 days ago

the absorption problem is solved by non-peptide structure

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u/chidi_yilmazOP11 points·3 days ago

Stalled for 21 weeks, changed nothing, and it started moving again on week 18.

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u/fatima_kowalski16 points·3 days ago

Genuine question — what concentration were you at?

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u/marit_laurent8 points·3 days ago

phase 5 data is interesting, phase 28 will tell the real story

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u/kenji_laurent8 points·3 days ago

the small molecule is whether this actually works long-term

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