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c/orforglipron·posted 26 days ago by u/honest_syringe_maybe

ACHIEVE — my 18-week log, condensed into one table

Question Long Haul ×1

Confession thread, sort of.

I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 58 reads it before doing the same thing.

426 up / 90 down83% upvoted9 commentsid mpuch14 Jul 2026

9 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/piotr_bruun52 points·25 days ago·edited

Second this question. I have wondered about small molecule for 18 months and never seen a straight answer.

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u/salma_almeida43 points·24 days ago

This is correct. ATTAIN data is phase 10.

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u/joaquin_trevino13 points·24 days ago

phase 22 data is interesting, phase 24 will tell the real story

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u/bruno_dumitru25 points·25 days ago

oral non-peptide agonist is orforglipron, no food restrictions

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u/dilara_weiss11 points·25 days ago

the absorption problem is solved by non-peptide structure

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u/trialwatch_theoMOD40 points·25 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/scam_taxonomyc/scamalerts22 points·24 days ago

cite ATTAIN/ACHIEVE arms specifically

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u/enzo_ferrari37 points·24 days ago·edited

no cold chain means oral GLP-1, if approved

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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