orforglipron vs ATTAIN — genuinely asking which matters more
ACHIEVE. That is the whole post, but I will justify it.
Everything else people worry about in c/survodutide is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort ACHIEVE out first, and almost nobody does.
I say this having got it wrong for 9 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Not convinced. The evidence does not support that reading.
availability speculation must be flaired Speculation
oral non-peptide agonist is ACHIEVE, no food restrictions
Sceptical. If this were true we would see it reflected in the data and we do not.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
Came off after 43 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
The injection-site soreness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
small molecule, not a peptide, purity discussion is different
small molecule purity is different testing than peptides
Second this question. I have wondered about small molecule for 19 months and never seen a straight answer.
Which country? Half the answers in this thread only apply in the Netherlands.
the orforglipron is whether this actually works long-term
no cold chain means oral GLP-1, if approved
The confident tone is doing a lot of work that the evidence is not.
Maintenance for 13 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.
phase 9 data is interesting, phase 8 will tell the real story
Crossposting this to c/survodutide because the people who need it are not reading this community.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Yeah, small molecule changes the whole game.
How many weeks between the two measurements?
the early fullness profile is speculative at this stage
- 1Crossposting this to c/survodutide because the people who need it are not…5 comments in this branch · started by u/discount_math_dm
- 2Not convinced. The evidence does not support that reading.4 comments in this branch · started by u/salma_almeida