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c/orforglipron·submitted 2 months ago by u/lucia_bruun

[Meta] the small molecule rule is doing its job and people should stop complaining

Paperbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 19 months without either producing anything. What would actually settle it is 19 people measuring the…

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5 comments, started 2 months ago
u/first_hundred-11 points·2 months ago

small molecule, not a peptide, purity discussion is different

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u/neha_mwangi1 point·2 months ago

You have restated the marketing copy. What is the actual substance here.

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u/cloudy_vial_carol1 point·2 months ago

cite ATTAIN/ACHIEVE arms specifically

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u/paloma_stanescu1 point·2 months ago

small molecule, not a peptide, purity discussion is different

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/reship_roulette1 point·2 months ago

small molecule purity is different testing than peptides

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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