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c/newbiequestions·posted 3 months ago by u/fabio_nkemelu

normal: what the trials say vs what this community says

Wiki Long Haul ×8 The Quiet One ×1

Confession thread, sort of.

I went from 7.5mg to 2.4mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have early fullness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 93 reads it before doing the same thing.

1,930 up / 673 down74% upvoted50 commentsid u6kq5d13 Apr 2026

50 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/gentle_correctionMOD184 points·3 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/low_appetite_lisa46 points·3 months ago

what is titration — it means going slow on the escalation

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u/trialwatch_theotrial nerd142 points·3 months ago·edited

Are you on a pen or vial?

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u/teodor_jansen37 points·3 months ago

Not to be pedantic but beginner and normal are being used interchangeably and they are not interchangeable in real life.

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u/cato_batista29 points·3 months ago·edited

Respectfully this is a sample of one presented as a finding.

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u/farid_jansen9 points·3 months ago

what is a COA — certificate of analysis, document from the lab

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u/aurel_boateng116 points·3 months ago

Strongly agree. No question is dumb here.

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u/fabio_nkemeluOP66 points·3 months ago

Week 13 checking in: nothing on the scale, no nausea, wondering if the pen is broken. No, it is just week 13.

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u/adaeze_cabrera50 points·3 months ago

Small correction: the trial was 11 weeks, not 22. Does not change your point but people will quote it.

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u/nightowl_injector11 points·3 months ago

no question too basic, read the wiki first, then ask anyway

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u/ruben_almeida79 points·3 months ago

the first time question is not dumb

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u/nora_lundgren120 points·3 months ago·edited

link the wiki instead of retyping, but politely

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u/ruben_cabrera61 points·3 months ago

Week 23 or week 36?

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u/denied_again_d53 points·3 months ago

the first time question is not dumb

Disagree on that part. 98.1% and 97.6% on the same vial is normal.

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u/piotr_bruun15 points·3 months ago

Small correction: the trial was 14 weeks, not 10. Does not change your point but people will quote it.

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u/hassan_ostergaard63 points·3 months ago

Are you on a pen or vial?

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u/mariam_cabrera51 points·3 months ago

This is a good question, genuinely.

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u/fabio_nkemeluOP31 points·3 months ago

week two nothing happening — yes, that is normal

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u/ms_fragmenter20 points·3 months ago

what is a COA — certificate of analysis, document from the lab

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u/renal_outcomes_rnephro-curious-29 points·3 months ago

Yeah, that is totally normal for week 3.

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u/wholesome_lurker53 points·3 months ago

no question too basic, read the wiki first, then ask anyway

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u/saskia_rahimi33 points·3 months ago

Are you on a pen or vial?

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u/yusuf_kirchner33 points·3 months ago

Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/erez_perrin26 points·3 months ago·edited

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/old_account_202323 points·3 months ago

be kind, condescending answers are removed

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u/karma_irrelevant7 points·3 months ago

Strongly agree. No question is dumb here.

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u/liver_enzyme_liz2 points·3 months ago

the beginner question is not dumb

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u/teodor_jansen20 points·3 months ago

Week 18 checking in: nothing on the scale, no nausea, wondering if the pen is broken. No, it is just week 18.

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[deleted]8 points·3 months ago

[deleted]

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u/ruben_cabrera4 points·3 months ago

no dose recommendations for individuals, even here

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