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c/maintenancephase·posted 2 years ago by u/fatima_asante

15 months in and lowest effective dose is still the thing I get wrong

Meta Receipts ×2 Well Actually ×3

long term. That is the whole post, but I will justify it.

Everything else people worry about in c/intlshipping is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort long term out first, and almost nobody does.

I say this having got it wrong for 21 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

2,069 up / 397 down84% upvoted15 commentsid ogt8i417 Jan 2024

15 comments

8 in this archive, depth 4

best — the order this archive was captured in

u/noor_vermeulen144 points·2 years ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/nhs_waitlist_nUK113 points·2 years ago·edited

Mechanistically the bit that matters is goal weight. It explains most of the early profile and a decent chunk of the outcome.

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u/sanne_delgado45 points·2 years ago

You have restated the marketing copy. What is the actual substance here.

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u/andres_dahlberg75 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/marisol_frisk21 points·2 years ago·edited

Half-life is about 168 hours, so steady state lands around week 14–5. Practical consequence: what you feel in week 1 is not what that dose does.

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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c/maintenancephase rules
  1. State how long you have been at maintenance. "Maintenance" at week 30 is not maintenance.
  2. Regain is not a moral failing and posts implying it is get removed.
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