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c/maintenancephase·posted 2 years ago by u/cold_chromatogram_only

goal weight is the most under-discussed thing in c/trialwatch

Discussion The Quiet One ×3

Been lurking in c/retatrutide for about 23 months and finally have something worth posting.

Short version: week 93, 1.0mg, and lowest effective dose is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 13 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 4.

560 up / 169 down77% upvoted15 commentsid 1rbcr412 Jun 2024

15 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/osman_ferrari64 points·2 years ago

Regain on a taper is expected. 14% back over 28 weeks, which matches the discontinuation data. Planned for it.

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u/kaplan_meier_kim22 points·2 years ago·edited

Weight variance within what range?

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u/priya_weiss-29 points·2 years ago

Did you stretch the dose interval?

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u/rafael_krastev1 point·2 years ago

the plateau is where the learning happens

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u/nadia_nascimento1 point·2 years ago

Did you stretch the dose interval?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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[removed]1 point·2 years ago

[removed by moderator]

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u/ilias_nakamura1 point·2 years ago

Strongly agree. Lowest effective dose is a real discovery process.

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u/elise_ramos1 point·2 years ago

regain after taper is expected, plan for it

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u/vitamin_d_void1 point·2 years ago

Yeah, maintenance is the boring part and the important part.

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u/yara_antonsen30 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/enzo_danquah25 points·2 years ago·edited

regain is not a moral failing

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u/ilias_nakamura39 points·2 years ago

Rodent data is rodent data.

Yes, exactly this, and it is the bit that took me 18 weeks to accept.

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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  1. State how long you have been at maintenance. "Maintenance" at week 30 is not maintenance.
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