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c/maintenancephase·posted 1 year ago by u/nils_tulloch

[Question] how do you actually verify dose stretching

Question Receipts ×8

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking maintenance against eGFR for 15 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

418 up / 131 down76% upvoted19 commentsid 1po9q121 Sep 2024

19 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/hub_opssite staff23 points·1 year ago

This is correct. Weight variance is normal at maintenance.

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u/paloma_stanescu6 points·1 year ago

Maintenance for 10 months now. 5mg every 25 days, weight 5±10kg. Found the rhythm.

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u/liv_kuipers3 points·1 year ago

Maintenance for 10 months now.

Disagree on that part. 98.7% and 98.9% on the same vial is normal.

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u/aurel_mwangi22 points·1 year ago
tl;dr for anyone scrolling: maintenance
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u/laila_almeida15 points·1 year ago

weight moves within 14kg and that is normal

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u/incretin_ivypharmacology4 points·1 year ago

regain is not a moral failing

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u/tomas_lokken6 points·1 year ago

Did you stretch the dose interval?

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u/paloma_stanescu3 points·1 year ago

Yeah, maintenance is the boring part and the important part.

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u/nils_tullochOP15 points·1 year ago

the lowest dose you can stay on is not the lowest dose that works

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u/rafael_krastev7 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/arne_ndiaye2 points·1 year ago

regain is not a moral failing

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u/food_noise_goneMOD12 points·1 year ago

Tracking number removed. It identifies both ends of a shipment.

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u/line_bergstrom0 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/viktor_erdogan1 point·1 year ago·edited

Weight variance within what range?

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u/teodor_duarte8 points·1 year ago

food noise returns but not always immediately

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u/hedda_aguirre5 points·1 year ago

Mechanistically the bit that matters is dose stretching. It explains most of the early profile and a decent chunk of the outcome.

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u/karim_hartmann6 points·1 year ago

nobody posts about this part and it is the longest part

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About c/maintenancephase

The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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  1. State how long you have been at maintenance. "Maintenance" at week 30 is not maintenance.
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