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c/glp1science·submitted 4 months ago by u/ferran_batista

receptor: what the trials say vs what this community says

Speculationbranch of 9 comments

Right, the mechanism question again, but with numbers this time. I have 2 data points over 40 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…

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9 comments, started 4 months ago
u/milan_mensah-24 points·4 months ago

Yeah, the incretin mechanism is doing the work here.

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u/wholesome_lurker1 point·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/trialwatch_theotrial nerd1 point·4 months ago·edited

Strongly agree. Central appetite is real but people overstate it.

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u/noor_hovland1 point·4 months ago

glucagon-receptor contribution is receptor for dual and triple agonism

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u/niels_roos1 point·4 months ago

incretin physiology is receptor, the mechanism layer

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u/milos_vanhecke1 point·4 months ago

do not extrapolate rodent data to human dosing without saying so

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u/rina_bergstrom1 point·4 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/vomit_free_since1 point·4 months ago

Is that mechanism or speculation?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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