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Single comment threadYou are looking at one branch of [Vendor] WXT order #17 — Germany, 9 days, no drama, receipts inside — 56 comments in the full submission. View in context.
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c/glp1science·submitted 1 year ago by u/bastian_eriksen

[Vendor] WXT order #17 — Germany, 9 days, no drama, receipts inside

Speculationbranch of 6 comments

Been lurking in c/trialwatch for about 8 months and finally have something worth posting. Short version: week 35, 0.5mg, and incretin is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 31 threads, and the answers split roughly down the middle. What I actually want to know…

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6 comments, started 1 year ago
u/emeka_chowdhury268 points·1 year ago

Yeah, the incretin mechanism is doing the work here.

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u/osman_eriksen168 points·12 months ago

rodent pharmacology tells you what to investigate, not what to expect in humans

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u/camila_lindqvist65 points·12 months ago

This is correct. Rodent data is investigational, not predictive.

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u/hassan_ostergaard85 points·1 year ago

gastric emptying is real and explains most early reflux

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u/sig_figs_samMOD159 points·1 year ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/trialwatch_theotrial nerd78 points·1 year ago

Flair changed to match the content.

Yes, exactly this, and it is the bit that took me 93 weeks to accept.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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