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c/glp1science·submitted 2 years ago by u/fatima_kowalski

switched from 0.25mg to 15mg and the muscle cramps got better, not worse

Paperbranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that pharmacology is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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7 comments, started 2 years ago
u/nhs_waitlist_nUK91 points·2 years ago

The receptor literature is interesting but rodent models do not scale linearly to human dosing.

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u/incretin_ivyMOD58 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/dose_creep_dan-21 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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u/niels_roos24 points·2 years ago

receptor distribution matters, GLP-1 is not everywhere

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u/noor_hovland11 points·2 years ago

do not extrapolate rodent data to human dosing without saying so

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