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c/glp1science·posted 1 year ago by u/piotr_grimaldi

someone explain half-life to me like I have not read a paper in years

Needs Source

Posting this because I searched for it and got nothing useful.

Setup: 1.7mg, week 35, sulphur burps present but not ruining anything. I changed exactly one variable — mechanism — and tracked it for 11 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

0 up / 0 down47% upvoted4 commentsid 1y03k227 Oct 2024

4 comments

4 in this archive, depth 2

best — the order this archive was captured in

u/kian_balogun5 points·1 year ago·edited
genuine question, not being difficult: how do you know
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u/piotr_grimaldiOP2 points·1 year ago

Receptor distribution explains why the food-noise thing hits gastric emptying but not receptor.

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u/elin_lundgren1 point·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/osman_eriksen2 points·1 year ago

Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.

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About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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