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c/glp1science·submitted 2 years ago by u/swirl_dont_shake

[Lab] 21th independent test on QSC, and the trend is the interesting part

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gastric emptying. That is the whole post, but I will justify it. Everything else people worry about in c/survodutide is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does. I say this having got it wrong for 16…

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5 comments, started 2 years ago
u/enzo_danquah637 points·2 years ago

Respectfully this is a sample of one presented as a finding.

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u/annika_fonseca399 points·2 years ago

the 6-day half-life means week 6 is still ramp-up pharmacokinetically

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u/bastian_ekstrom195 points·2 years ago

That is net peptide content, not purity. Different number, different meaning.

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u/anders_kuusela66 points·2 years ago·edited

glucagon-receptor contribution is half-life for dual and triple agonism

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u/zeynep_villalobos471 points·2 years ago

Respectfully this is a sample of one presented as a finding.

Adding to this: mechanism is doing more work than the comment implies.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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