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c/glp1science·submitted 2 years ago by u/laila_almeida

[Discussion] can we stop arguing about appetite until somebody posts a number

Discussionbranch of 4 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that half-life is important. I believe it, but I have never seen anyone show why, and when I search I get 19 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because…

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4 comments, started 2 years ago
u/milan_mensah234 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/laila_almeidaOP342 points·2 years ago

I am going to push back on this slightly.

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u/bastian_ekstrom0 points·2 years ago

I am going to push back on this slightly.

Yes, exactly this, and it is the bit that took me 58 weeks to accept.

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u/laila_almeidaOP209 points·2 years ago

Which paper are you quoting?

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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