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c/glp1science·submitted 1 months ago by u/signe_boateng

someone explain gastric emptying to me like I have not read a paper in years

Explainerbranch of 7 comments

Quick one. Canada here. pharmacology works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 8 weeks and cost roughly what I expected. The admin was worse than…

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7 comments, started 1 months ago
u/devils_advocate_d324 points·1 months ago

gastric emptying is real and explains most early fatigue

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u/greta_lokken224 points·1 months ago

amylin is not GLP-1, posts conflating them get corrected

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u/devils_advocate_d150 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/analog_alphabet124 points·1 months ago

the 22-day half-life means week 22 is still ramp-up pharmacokinetically

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u/lina_ndiaye126 points·1 months ago

Not to be pedantic but incretin and mechanism are being used interchangeably and they are not interchangeable in real life.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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