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[Explainer] why an oral non-peptide escapes the absorption problem entirely
Something I noticed reading old threads that I have not seen said out loud. The advice on gastric emptying in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory…
rodent half-life tells you what to investigate, not what to expect in humans
incretin physiology is incretin, the mechanism layer
incretin physiology is pharmacology, the mechanism layer
The half-life is 9 hours, which means week 9 is genuinely still ramp-up. Week 4 is steady state.
The half-life literature is interesting but rodent models do not scale linearly to human dosing.