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c/glp1science·submitted 23 days ago by u/camila_kowalski

[Needs Source] "it heals your metabolism" is not a mechanism

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Genuinely asking, not being difficult. Everyone in c/tapering repeats that mechanism is important. I believe it, but I have never seen anyone show why, and when I search I get 5 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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4 comments, started 21 days ago
u/signe_boateng25 points·21 days ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/camila_kowalskiOP17 points·21 days ago

central appetite signalling is real but people overweight it

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u/signe_boateng19 points·21 days ago

central appetite signalling is real but people overweight it

Adding to this: mechanism is doing more work than the comment implies.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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