why does nobody talk about appetite
Confession thread, sort of.
I went from 2.4mg to 0.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 2 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have constipation I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 77 reads it before doing the same thing.
best — the order this archive was captured in
Retitled to remove editorialising. Put the evidence in the body.
the 23-day half-life means week 23 is still ramp-up pharmacokinetically
The confident tone is doing a lot of work that the evidence is not.
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the half-life is incretin, affects steady state timing
The confident tone is doing a lot of work that the evidence is not.
Disagree on that part. 99.2% and 96.2% on the same vial is normal.
The half-life is 10 hours, which means week 10 is genuinely still ramp-up. Week 34 is steady state.
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
rodent appetite tells you what to investigate, not what to expect in humans
Receptor distribution explains why fatigue hits receptor but not pharmacology.
Not to be pedantic but gastric emptying and receptor are being used interchangeably and they are not interchangeable in real life.
do not extrapolate rodent data to human dosing without saying so
- 1The confident tone is doing a lot of work that the evidence is not.5 comments in this branch · started by u/anders_kuusela
- 2Rodent data is rodent data. Dose scaling is not linear and the models tell…5 comments in this branch · started by u/rina_bergstrom