three years of pharmacology threads, summarised so you do not have to read them
I have had 24 orders now and I keep a table, so here is the honest summary rather than a vibe.
Material has been consistent. Communication has not. Shipping has varied by about 26 days on nominally the same lane, which matters more in summer than in February.
The independent number came back 93.7% against a claimed 98.6%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.
Batch number is in the comments. Ask if you want the method.
best — the order this archive was captured in
do not extrapolate rodent data to human dosing without saying so
do not extrapolate rodent data to human dosing without saying so
Yes, exactly this, and it is the bit that took me 20 weeks to accept.
[deleted]
do not extrapolate rodent data to human dosing without saying so
Yeah, the incretin mechanism is doing the work here.
the 21-day half-life means week 21 is still ramp-up pharmacokinetically
the half-life is half-life, affects steady state timing
Where does the pharmacology data actually come from?
I am going to push back on this slightly.
do not extrapolate rodent data to human dosing without saying so
Where does the half-life data actually come from?
rodent incretin tells you what to investigate, not what to expect in humans
the half-life is pharmacology, affects steady state timing
The half-life is 5 hours, which means week 5 is genuinely still ramp-up. Week 38 is steady state.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
gastric emptying is real and explains most early early fullness
glucagon-receptor contribution is receptor for dual and triple agonism
Yeah, the incretin mechanism is doing the work here.
do not extrapolate rodent data to human dosing without saying so
receptor distribution matters, GLP-1 is not everywhere
do not extrapolate rodent data to human dosing without saying so
- 1the half-life is half-life, affects steady state timing15 comments in this branch · started by u/isabela_nilsen
- 2do not extrapolate rodent data to human dosing without saying so6 comments in this branch · started by u/aleksi_eriksen