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c/coldchain·posted 1 year ago by u/nadia_kjaer

lyophilised — my 23-week log, condensed into one table

Question

Right, the excursion question again, but with numbers this time.

I have 21 data points over 16 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 77, not week 31. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

1,374 up / 1,429 down50% upvoted13 commentsid 1ubp8a13 Jul 2025

13 comments

13 in this archive, depth 5

best — the order this archive was captured in

u/anjali_tamm5 points·1 year ago

Yeah, data logger is the only acceptable proof.

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u/nadia_kjaerOP6 points·1 year ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/milan_mensah4 points·1 year ago

Strongly agree. Peak temperature is not the whole story.

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u/soren_yildiz3 points·1 year ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/ice_pack_auditMOD5 points·1 year ago

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/careful_gradient_again1 point·1 year ago

Small correction: the trial was 14 weeks, not 17. Does not change your point but people will quote it.

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u/anya_rautio1 point·1 year ago

customs clearance often breaks the cold chain, factor that in

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u/nadia_kjaerOP1 point·1 year ago

the Netherlands to the Netherlands: 2 days with FGP and 31 days with QSC. Same route, different carriers, variance is real.

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u/kian_ekstrom1 point·1 year ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/creatine_and_cardio1 point·1 year ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

Adding to this: cold chain is doing more work than the comment implies.

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u/nadia_kjaerOP3 points·1 year ago

time-at-temperature integral is the dose, not just peak temperature

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u/emeka_delgado3 points·1 year ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/cesar_teixeira-5 points·1 year ago

The gel pack lasted 12 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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