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c/coa·submitted 11 months ago by u/tidy_vialdrawer_watch

19 months in and purity is still the thing I get wrong

COAbranch of 6 comments

Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have…

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6 comments, started 11 months ago
u/dario_boateng434 points·11 months ago·edited

Asked TFC for the batch-specific COA and they sent it within six hours, full document, batch number, date, everything. That is the baseline.

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u/tidy_vialdrawer_watchOP309 points·11 months ago

Sent one vial to PeptideMeter and VendorInvestigate. 96.8% and 99.1%. Cost me more than the vial did and I would do it again.

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u/sig_figs_sammod · analytical344 points·10 months ago·edited

the method line is doing real work, not just window dressing

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u/tidy_vialdrawer_watchOP178 points·10 months ago

Did they give you the chromatogram or just the summary line?

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u/tidy_vialdrawer_watch137 points·10 months ago·edited

This is the correct framing. The COA structure matters as much as the number.

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u/dario_vermeulen57 points·10 months ago

the method line is doing real work, not just window dressing

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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