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c/coa·posted 5 months ago by u/laila_wojcik

unpopular opinion: COA is massively overrated

Explainer Receipts ×6

Trying to settle this properly because the thread from last year went in circles.

The claim: batch matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 3 months without either producing anything.

What would actually settle it is 19 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

522 up / 15 down97% upvoted27 commentsid vjh9ow12 Feb 2026

27 comments

19 in this archive, depth 4

best — the order this archive was captured in

u/aleksi_eriksen79 points·5 months ago
n=1 but same
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u/honest_syringe2433 points·5 months ago

chromatogram or it did not happen

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u/emeka_chowdhury45 points·5 months ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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[deleted]33 points·5 months ago

[deleted]

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u/nadia_kjaer8 points·5 months ago

the counterion is part of the mass you paid for

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u/spreadsheet_gremlindata11 points·5 months ago

PDF metadata is checkable in fifteen seconds

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u/alcohol_aversion36 points·5 months ago

What were the related substances listed individually?

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u/karma_irrelevant12 points·5 months ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/yara_antonsen10 points·5 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/laila_yilmaz8 points·5 months ago

no "is this good?" without saying what the compound and claimed purity are

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u/valeria_girard19 points·5 months ago

area% is not mass%, and here is exactly why it matters

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u/isabela_nilsen0 points·5 months ago

I am going to push back on this slightly.

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u/nikhil_lindqvist10 points·5 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/purity_pedantMOD5 points·5 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/hugo_bergstrom0 points·5 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/cormac_pereira1 point·5 months ago

the batch number or it did not happen

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u/laila_wojcikOP1 point·5 months ago

Not to be pedantic but water content and related substances are being used interchangeably and they are not interchangeable in real life.

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u/valeria_karlsen3 points·5 months ago

Rodent data is rodent data.

Adding to this: purity is doing more work than the comment implies.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
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