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Single comment threadYou are looking at one branch of switched from 12.5mg to 0.5mg and the injection-site soreness got better, not worse — 36 comments in the full submission. View in context.
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c/coa·submitted 1 year ago by u/rania_okonkwo

switched from 12.5mg to 0.5mg and the injection-site soreness got better, not worse

Explainerbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: COA matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 7 months without either producing anything. What would actually settle it is 39 people measuring the same thing…

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This branch

5 comments, started 1 year ago
u/sofia_danquah796 points·1 year ago·edited

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/rania_okonkwoOP537 points·1 year ago

Water content was 3.8%, acetate was 6.2%, purity was 99%, but net peptide was only 90% of the label weight. Perfectly honest, just chemistry.

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u/rania_okonkwoOP350 points·1 year ago·edited

the method line is doing real work, not just window dressing

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[deleted]130 points·1 year ago

[deleted]

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u/yara_antonsen127 points·1 year ago

the batch number or it did not happen

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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Independent HPLC and mass spec. The number you get is the number they found.

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