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c/coa·posted 2 years ago by u/liv_nkemelu

[Discussion] purity is doing more work than we give it credit for

Discussion Long Haul ×2 Cold Box ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking related substances against triglycerides for 11 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,122 up / 911 down77% upvoted30 commentsid 1w3s8t26 Apr 2024

30 comments

13 in this archive, depth 3

best — the order this archive was captured in

u/dario_boateng375 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/wanjiru_varga112 points·2 years ago

axis labels included, always

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u/liv_nkemeluOP67 points·2 years ago

axis labels included, always

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u/liv_nkemeluOP267 points·2 years ago

The chromatogram trace is where the real information lives. The summary number is just a headline.

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u/clara_restrepo126 points·2 years ago

no "is this good?" without saying what the compound and claimed purity are

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u/liv_nkemeluOP-24 points·2 years ago

Metadata check caught a COA that was created in a browser four months after the analysis date. Not evidence of fraud, but worth flagging to QSC.

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u/low_appetite_lisa62 points·2 years ago

purity and net content are two different numbers, same vial

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u/wrong_network_w250 points·2 years ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/hassan_chowdhury60 points·2 years ago

Did they give you the chromatogram or just the summary line?

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u/tidy_vialdrawer_watch35 points·2 years ago

area% is not mass%, and here is exactly why it matters

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u/aleksi_eriksen164 points·2 years ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/tidy_vialdrawer_pls129 points·2 years ago

Yeah, 96.8% area is not the problem, the missing impurity breakdown is the problem.

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u/coa_janitorMOD90 points·2 years ago

Tracking number removed. It identifies both ends of a shipment.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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