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c/cagrilintide·submitted 18 days ago by u/egfr_watcher

[Trial Data] nausea rates in the combination arm vs sema alone

Trial Databranch of 8 comments

Right, the amylin question again, but with numbers this time. I have 11 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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8 comments, started 17 days ago
u/amylin_amyamylin22 points·17 days ago

long-acting amylin is co-agonism, different satiety profile

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u/ledger_modMOD13 points·17 days ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/egfr_watcherOP5 points·17 days ago

REDEFINE phase 21 readouts are interesting but 21 person REDEFINE is different from 21 trial REDEFINE.

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[removed]4 points·17 days ago

[removed by moderator]

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u/ice_pack_auditcold chain6 points·16 days ago

the mechanism is different, the side effect profile reflects it

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u/egfr_watcher7 points·17 days ago

This is correct. The co-agonism is real.

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u/amara_halonen5 points·16 days ago

long-acting amylin is CagriSema, different satiety profile

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u/egfr_watcherOP2 points·16 days ago

long-acting amylin is CagriSema, different satiety profile

Adding to this: amylin is doing more work than the comment implies.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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