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c/cagrilintide·submitted 1 year ago by u/noor_vermeulen

small win: REDEFINE stopped being a problem at week 21

Labbranch of 7 comments

Quick one. Canada here. CagriSema works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 11 weeks and cost roughly what I expected. The admin was worse than the…

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7 comments, started 1 year ago
u/noor_ivaturi108 points·1 year ago

amylin receptor distribution is different from GLP-1

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u/freya_baptista72 points·1 year ago

amylin receptor distribution is different from GLP-1

Adding to this: REDEFINE is doing more work than the comment implies.

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u/wrong_network_w55 points·1 year ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/ines_ekstrom30 points·1 year ago

the mechanism is different, the side effect profile reflects it

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u/lane_map_larrylogistics-5 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/noor_vermeulenOP1 point·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/amara_kuipers1 point·1 year ago

CagriSema is a fixed combo in trials, not user-mixed

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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