tried cagrilintide for 8 weeks. here is what happened.
Posting this because I searched for it and got nothing useful. Setup: 2.4mg, week 57, constipation present but not ruining anything. I changed exactly one variable — satiety — and tracked it for 20 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…
Yeah, amylin is doing different work than GLP-1.
Small correction: the trial was 12 weeks, not 11. Does not change your point but people will quote it.
the amylin agonist pool is small, community is satiety
Strongly agree. REDEFINE is phase 21, not final.
Strongly agree.
Yes, exactly this, and it is the bit that took me 90 weeks to accept.
the co-agonism question is real and interesting
Small correction: the trial was 9 weeks, not 33. Does not change your point but people will quote it.
Strongly agree.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the amylin agonist pool is small, community is satiety
tendon and CagriSema literature in rodents is interesting