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c/cagrilintide·submitted 4 months ago by u/ferritin_low

[Discussion] amylin is doing more work than we give it credit for

Discussionbranch of 4 comments

Something I noticed reading old threads that I have not seen said out loud. The advice on REDEFINE in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…

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4 comments, started 4 months ago
u/zeynep_zielinski15 points·4 months ago·edited

Strongly agree. REDEFINE is phase 5, not final.

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u/aa_analysis_andy5 points·4 months ago·edited

the mechanism is different, the side effect profile reflects it

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u/hydration_hank7 points·4 months ago

Yeah, amylin is doing different work than GLP-1.

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u/tove_vasquez22 points·4 months ago

long-acting amylin is co-agonism, different satiety profile

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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