GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of [Question] how do you actually verify REDEFINE — 44 comments in the full submission. View in context.
2.3k
c/cagrilintide·submitted 1 year ago by u/zeynep_weiss

[Question] how do you actually verify REDEFINE

Questionbranch of 11 comments

Been lurking in c/cryptopay for about 12 months and finally have something worth posting. Short version: week 52, 2.4mg, and REDEFINE is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 17 threads, and the answers split roughly down the middle. What I actually want to know…

Read the full submission and all 44 comments →

This branch

11 comments, started 1 year ago
u/niels_norgaard162 points·1 year ago

long-acting amylin is co-agonism, different satiety profile

replysharereportpermalink
u/andres_dahlberg126 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

replysharereportpermalink
u/emeka_chowdhury52 points·1 year ago

This is correct. The co-agonism is real.

replysharereportpermalink
u/lucia_bruun82 points·1 year ago

the mechanism is different, the side effect profile reflects it

replysharereportpermalink
u/runa_pires105 points·1 year ago

REDEFINE which arm?

replysharereportpermalink
u/hedda_aguirre37 points·1 year ago

long-acting amylin is CagriSema, different satiety profile

replysharereportpermalink
u/zeynep_weissOP19 points·1 year ago

REDEFINE phase 2 readouts are interesting but 2 person cagrilintide is different from 2 trial cagrilintide.

replysharereportpermalink
u/controversial_only37 points·1 year ago

Slight fix: the number was 98.0, not 98.1. Decimal point, but a fairly consequential one.

replysharereportpermalink
u/forest_plot_fionastats76 points·1 year ago

long-acting amylin is co-agonism, different satiety profile

Yes, exactly this, and it is the bit that took me 50 weeks to accept.

replysharereportpermalink
u/nl_verzekering29 points·1 year ago

not approved anywhere, keep posts descriptive, not instructional

replysharereportpermalink
u/zeynep_weissOP16 points·1 year ago

not approved anywhere, keep posts descriptive, not instructional

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

replysharereportpermalink

← back to the whole thread

About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

19kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.com
Sponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
c/cagrilintide rules
  1. Amylin is not a GLP-1. Posts conflating them get corrected.
  2. CagriSema ratios in trials are fixed-dose. Do not extrapolate to self-mixing.
  3. Not approved anywhere. Keep posts descriptive, not instructional.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.