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c/bloodwork·posted 1 year ago by u/osman_eriksen

stalled for 20 weeks at 10mg and I refuse to panic this time

Discussion Receipts ×3

eGFR. That is the whole post, but I will justify it.

Everything else people worry about in c/orforglipron is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort eGFR out first, and almost nobody does.

I say this having got it wrong for 19 months. My fasting insulin was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

1,242 up / 391 down76% upvoted27 commentsid 17ymbk9 Mar 2025

27 comments

14 in this archive, depth 4

best — the order this archive was captured in

u/a1c_arcMOD71 points·1 year ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/andres_restrepo26 points·1 year ago

eGFR noise during rapid loss is expected

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u/emeka_chowdhury44 points·1 year ago

Strongly agree. ALT is where you catch the liver story early.

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u/copay_card_cc48 points·1 year ago

Same lab both times?

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u/a1c_arcT2D20 points·1 year ago

ApoB over LDL-C, that is the hierarchy

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u/kaia_kuusela31 points·1 year ago
controversial sort brought me here and it was worth it
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u/leila_vasquez25 points·1 year ago

Strongly agree. ALT is where you catch the liver story early.

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u/osman_eriksenOP-13 points·1 year ago

controversial sort brought me here and it was worth it

Adding to this: ApoB is doing more work than the comment implies.

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u/chidi_abubakar1 point·1 year ago

TSH from 9 to 22 is movement, not noise

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u/no_refunds_nr1 point·1 year ago

Strongly agree. ALT is where you catch the liver story early.

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u/cardio_endpoint_c15 points·1 year ago

eGFR noise during rapid loss is expected

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u/yara_boateng7 points·1 year ago

HOMA-IR is crude but free and useful for tracking

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[removed]5 points·1 year ago

[removed by moderator]

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About c/bloodwork

What to measure before you start, what to re-measure, and how to interpret movement without panicking. ApoB over LDL-C, HOMA-IR as a crude free tool, ALT and the fatty-liver story, eGFR noise during rapid loss, and the deficiencies that a 1,100-calorie appetite will hand you.

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