u/yannick_salinas

Not convinced. The evidence does not support that reading.

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

Titration means going slow. The 10mg is the starter, not the dose you stay on, not the dose you need to feel it.

the amylin agonist pool is small, community is satiety

Yeah, that is totally normal for week 9.

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

Which trial and what was the primary endpoint?

Sceptical. If this were true we would see it reflected in the data and we do not.

what is bac water — bacteriostatic water, preservative included

Yes, exactly this, and it is the bit that took me 62 weeks to accept.

Pens or research vials?

press release TRIUMPH posts must be flaired until a publication exists

the relative risk reduction in headlines is not the whole story

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.

This is the "correlation is mechanism" thing again. You changed three variables at once.

That is net peptide content, not purity. Different number, different meaning.

Phase 2 TRIUMPH looked amazing. Phase 3 trials are harder. Do not anchor on phase 2 readouts.

Half-life is about 168 hours, so steady state lands around week 22–5. Practical consequence: what you feel in week 1 is not what that dose does.

The first time question took me three weeks to understand. Wiki explained it eventually.