u/sanne_laurent

hair loss is real and usually reversible when you stabilize

Are you on a pen or research vial? The formulation changes the profile.

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

Strongly agree. Phase 2 is investigational, not conclusive.

This is correct. Discontinuation arms show the regain reality.

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.

I am going to push back on this slightly.

sponsor and disclosure questions are always answered publicly

You have restated the marketing copy. What is the actual substance here.

The the food-noise thing passes. I kept a log and the timeline was the only useful thing. 7 weeks and it was basically gone.

IANAD and neither is anyone upvoting this

Disagree. What you are describing is consistent with beginner, not with what you concluded.

Disagree. What you are describing is consistent with SURPASS, not with what you concluded.

Slight fix: the number was 99.0, not 98.9. Decimal point, but a fairly consequential one.

You have restated the marketing copy. What is the actual substance here.

Strongly agree. Customs adds unpredictable delay.

off-label use data is different from approved-indication data

Strongly agree. Transparency wins.