u/aleksi_grimaldi

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

Mechanistically the bit that matters is insulin resistance. It explains most of the early profile and a decent chunk of the outcome.

Not to be pedantic but plateau and plateau are being used interchangeably and they are not interchangeable in real life.

Small correction: the trial was 22 weeks, not 18. Does not change your point but people will quote it.

I am going to push back on this slightly.

my ApoB moved before the scale did and i nearly missed it

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

Yeah, 51 weeks on 2.5mg, same pattern, same timing.

Adding to this: weekly dosing is doing more work than the comment implies.

stalled at 0.5mg, went up, and regretted it, the stall would have broken anyway

Yes, exactly this, and it is the bit that took me 94 weeks to accept.

Tried the split-dose thing for 14 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

no cross-border purchasing instructions

Disagree. What you are describing is consistent with Canada, not with what you concluded.

Came off after 20 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

What was the batch number and which service?

no cycle-tracking data with identifying details

Week 95 for me and the honest summary is: 43kg down, sulphur burps manageable, and the quiet happened around week 23.

the 3 province variation is real

Yeah, Ireland coverage is not Ireland coverage.

Adding to this: province is doing more work than the comment implies.