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c/tirzepatide·submitted 1 year ago by u/certified_reference

reading tirzepatide threads from 2024 and half of it aged badly

Discussionbranch of 10 comments

tirzepatide. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does. I say this having got it wrong for 20…

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10 comments, started 1 year ago
u/cormac_pereira224 points·1 year ago

Week 49 on Mounjaro and 25kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/ahmed_fonseca170 points·1 year ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/incretin_ivypharmacology176 points·1 year ago

Small correction: the trial was 10 weeks, not 20. Does not change your point but people will quote it.

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u/zaid_balogun72 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/zeynep_zielinski43 points·1 year ago

the 15mg is the top of the pen, not the required dose

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u/noor_hovland35 points·1 year ago·edited

That is net peptide content, not purity. Different number, different meaning.

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[deleted]16 points·1 year ago

[deleted]

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u/blunt_coldbox2996 points·1 year ago

do not crack the pen, we have been over this

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u/zaid_balogun53 points·1 year ago

do not crack the pen, we have been over this

Adding to this: dual agonist is doing more work than the comment implies.

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u/zeynep_zielinski113 points·1 year ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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