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c/tirzepatide·submitted 2 months ago by u/mikkel_ogunleye

unpopular opinion: Zepbound is massively overrated

Side Effectsbranch of 4 comments

I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 24 days on nominally the same lane, which matters more in summer than in February. The independent number came back 97.9% against a claimed…

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4 comments, started 2 months ago
u/dario_vermeulen15 points·2 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/forest_plot_fionastats12 points·2 months ago

The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.

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u/sanne_novak17 points·2 months ago·edited

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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